KCNMA1 and cardiac hypertrophy: GA has been studied for its potentially beneficial effects in relaxing guinea pig trachea (possibly involving BK channels, but for which the EC50 was 20 μM, >1000-fold higher than the EC50 for effects on Kv7.2/3) and reducing cardiac hypertrophy and preventing septic shock, but to our knowledge it has not been previously reported as an anticonvulsant or Kv7 channel modulator56–58.