GA has been studied for its potentially beneficial effects in relaxing guinea pig trachea (possibly involving BK channels, but for which the EC50 was 20 μM, >1000-fold higher than the EC50 for effects on Kv7.2/3) and reducing cardiac hypertrophy and preventing septic shock, but to our knowledge it has not been previously reported as an anticonvulsant or Kv7 channel modulator56–58. This evidence concerns the gene KCNQ2 and cardiac hypertrophy.