In the low-PSI (≤ 0.20) and low-FENa (≤ 0.65) groups, patients were significantly younger and had significantly lower systolic blood pressure, less comorbid diabetes and hypertension, lower serum albumin and total protein, higher estimated glomerular filtration rate (eGFR), lower proportions of global glomerulosclerosis, and less severe interstitial fibrosis and tubular atrophy (IFTA) compared with those who had higher PSI and FENa (Table 1). The gene discussed is ALB; the disease is diabetes mellitus.