As these affinities typically apply to self-peptides such as tumor-associated antigens we assessed the capability of SLAMF7 signals to enhance the cytotoxic responses of human CD8+ T cells, activated with NY-ESO-1-pulsed HLA-A2 of antigen-presenting spheres that delivered SLAMF7 signals by anti-SLAMF7 antibodies, recombinant SLAMF7 molecules, or not [44, 45]. This evidence concerns the gene CD8A and neoplasm.