TP53 and neoplasm: In comparison with the control group, the 37 downregulated gene sets of the etoposide-treated group could be classified into 4 groups: (1) tumor suppressor genes signaling pathway, such as the p53 signaling pathway; (2) cell tight junction, such as adhesion molecules and junction; (3) cell cycle; (4) cell transcription and metabolism (Supplementary Fig. 3A).