This instability promotes metastasis by maintaining autonomous TC responses to cytoplasmic DNA and acts as a primary driver of tumor evolution.20,57 In the invasive progression of non-small cell lung cancer (NSCLC), the activity of APOBEC3B induces incomplete replication and replication stress in the genome, triggering erroneous chromosome segregation, tightly associated with CIN and somatic mutation heterogeneity. This evidence concerns the gene APOBEC3B and non-small cell lung carcinoma.