For instance, in PD-L1-positive TNBC patients, atezolizumab combined with albumin-bound paclitaxel is an important therapeutic option for unmet treatment needs.322 In resectable CRC liver metastasis patients, adding perioperative systemic chemotherapy upon surgical resection increased PFS by 7%; however, perioperative treatment with cetuximab combined with chemotherapy significantly reduced PFS compared to chemotherapy alone. This evidence concerns the gene CD274 and colorectal carcinoma.