These N2-type neutrophils exhibit selective colonization in the lungs of tumor-free mice and release lipocalin 2 in a paracrine manner, contributing to the establishment of a conducive microenvironment for subsequent TC implantation.179 Similarly, particulate matter, a main component of air pollutants, induces TRAF6 accumulation via ROS-triggered, autophagy-dependent degradation of TRIM37 in alveolar epithelial cells, leading to increased NFκB pathway activation and enhanced chemokine production. Here, NFKB1 is linked to neoplasm.