CircEML4 from TAM-derived EVs also serves as a diagnostic biomarker for NSCLC.106 Experimental data indicate that cigarette-derived 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone activates the TMUB1/AKT pathway via METTL14/YTHDF2-mediated m6A modification, significantly correlating with increased cancer invasion and metastasis risk.107 The relationship between alcohol consumption and cancer remains inconclusive in both epidemiological studies and animal models. This evidence concerns the gene AKT1 and cancer.