TMUB1 and cancer: CircEML4 from TAM-derived EVs also serves as a diagnostic biomarker for NSCLC.106 Experimental data indicate that cigarette-derived 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone activates the TMUB1/AKT pathway via METTL14/YTHDF2-mediated m6A modification, significantly correlating with increased cancer invasion and metastasis risk.107 The relationship between alcohol consumption and cancer remains inconclusive in both epidemiological studies and animal models.