Genomic analysis reveals that abnormal mutations in tumor suppressor genes such as TP53, RB1, BRCA1, and cancer-related genes like C-MYC, KRAS, epidermal growth factor receptor (EGFR), and ALK in normal cells can lead to unchecked cell growth and proliferation, which are closely linked to the onset and progression of various cancer types. This evidence concerns the gene TP53 and cancer.