Fibroblasts, resident cells, and immune cells participate in this remodeling process.170 For instance, in HCC lung metastasis, the recruitment of CD11b + /CD45+ bone marrow-derived cells (BMDCs) to lung tissue is driven by the release of Lysyl Oxidase-like 2 by HCC cells, alongside significant upregulation of MMP9 and fibronectin expression in lung fibroblasts. Here, FN1 is linked to hepatocellular carcinoma.