Splicing events regulated by myosin phosphatase RHO-interacting protein and RBFOX2 are associated with PDA metastasis, cytoskeletal remodeling, and focal adhesion formation induction.46 Similarly, in breast cancer (BC) metastasis, the splicing factor SNRPA1 interacts with hundreds of structure-enhancing splicing enhancers enriched near cassette exons to promote cassette exon inclusion, enhancing BC cell invasion and lung colonization.47 Here, RBFOX2 is linked to breast cancer.