This educational interaction educates TCs to acquire highly dynamic and invasive phenotypes.148 And intracellular bacteria carried by CTCs can also enhance the durability of CTCs against fluid shear by regulating host-cell actin network.149 Furthermore, in vivo research indicates that in heterotypic TC clusters, low-motile cancer cells may be transported by mesenchymal stromal cells or cancer-associated fibroblasts in a Rac-dependent manner, thereby accelerating the pace of metastatic dispersion.145. The gene discussed is AKT1; the disease is cancer.