For instance, IL-22 derived from iNKT17 cells acts on endothelial cells (ECs) by inducing endothelial aminopeptidase N, promoting endothelial permeability and cancer cell migration.151 Matrix metalloproteinase 9 from monocytes within PMNs can also facilitate cancer cell extravasation by disrupting endothelial tight junctions.152 Furthermore, in obese mouse models, ROS produced by neutrophils have been found to increase the formation of NETs and weaken endothelial junctions. This evidence concerns the gene MMP9 and cancer.