ETV4 and neoplasm: Furthermore, we investigated the impact of the ETV4 P433L mutation and observed an increase in migration and cell stem-like properties, but not tumor proliferation (Fig. 3C and Supplementary Figure 7A-C).Notch, Hedgehog, and Wnt pathway are highly conserved signaling pathways that has significant implications for tumor homeostasis and stenness [67, 68].