Among individuals with T2DM (n = 6), morning-skewed energy intake (B:L:D = 10:20:70 compared with 30:40:30% TDEI) induced lower peak glucose, peak insulin, and insulin secretion rate in the morning but not in the afternoon and evening, despite no influence on 24-h mean glucose and insulin concentration [31]. This evidence concerns the gene INS and type 2 diabetes mellitus.