Similarly, some proteins related to nucleotide metabolism (ARFGAP1, ARL6IP5, & CDC42EP4), or cytoskeleton (EIF4G2, HDHD2, & TUBB4A), were downregulated in Rpe65−/−, but trending towards upregulation in RP mice. The gene discussed is TUBB4A; the disease is retinitis pigmentosa 1.