SNCA and Parkinson disease: However recent evidence underscores a more expansive view of PD, highlighting it as a systemic disorder that impacts a broad spectrum of neural circuits spanning both the central (CNS) and peripheral nervous systems (PNS) supported by genetic cellular analyses that identified mutations in genes like LRRK2, SNCA, GBA and VPS35, which not only influence cellular behavior in the CNS but have implications for cellular processes in the PNS (Chang et al., 2017; Korecka et al., 2019; Ma et al., 2021; Nalls et al., 2014; Simon-Sanchez et al., 2009).