PRDX5 and cancer: Gold complexes and auranofin effectivelygenerate reactive oxygen species (ROS) and inhibit thioredoxin reductase(TrxR),45,52 an essential enzyme that plays a crucialrole in maintaining cellular redox balance and protecting cells fromoxidative stress.53 Overexpression of TrxRhas been observed in different types of cancer cells, including coloncancer.54,55 Consequently, this biological activity ofgold complexes makes them a potential candidate for cancer therapy.