Here we describe the synthesisof new NSAID ligands, the corresponding phosphane gold(I) derivativesand their evaluation against colon cancer cells, studies of theirpossible mechanism through the inhibition of enzymes thioredoxin reductase(TrxR), cyclooxygenase (COX, isoforms 1 and 2), as well as redox disturbancesconsequence of ROS generation and the type of cell death. Here, PRDX5 is linked to malignant colon neoplasm.