PTGS1 and cancer: The antiproliferative effect of the most activecomplexes, [Au(L3)(JohnPhos)] (3b), [Au(L4)(CyJohnPhos)](4a) and [Au(L4)(JohnPhos)] (4b) againstcolon cancer cells (Caco2-/TC7) seems to be mediated by the inhibitionof the enzyme cyclooxygenase-1/2, modulation of reactive oxygen specieslevels by targeting thioredoxin reductase (TrxR) activity, and inductionof apoptosis in cancer cells.