FLG and Alzheimer disease: The concomitant presence of AD and FA seems to be more related to the evolution of the atopic march to the respiratory tract with the skin barrier breakdown, the increase in alarmins (TSLP, IL-25 and IL-33), reduction of filaggrins and changes in the microbiome.393, 407 In the case of AR, older children and adolescents may often no longer express the AD or FA of early childhood.393, 407