The preliminary analysis of C6orf120 gene expression across various human malignancies revealed a significant increase in C6orf120 expression in multiple cancers, including esophageal carcinoma (ESCA), head and neck squamous cell carcinoma (HNSC), LIHC, and lung squamous cell carcinoma (LUSC) (P < 0.05) (Figure 1A). The gene discussed is C6orf120; the disease is head and neck squamous cell carcinoma.