The results indicated that NFE2L2, NLRP3, DLAT, LIAS, and MTF1 were highly expressed in SLE patients, and LIPT1, DLAT, PDHB, GLS, GCSH, LIAS, and FDX1 were significantly downregulated in SLE patients (Figure 1A). The gene discussed is NLRP3; the disease is systemic lupus erythematosus.