These genes are PDHB, GLS, DLAT, FDX1, LIPT1, MTF1, LIAS, and DLST. The results showed that DLAT, DLAT and MTF1 were highly expressed in SLE patients, and LIPT1, DLAT, PDHB, GLS, LIAS and FDX1 were less expressed in SLE patients than in normal patients. The gene discussed is GLS; the disease is systemic lupus erythematosus.