TMPRSS4 and lung cancer: This further supports the idea that miR-149-3p can increase DDP sensitivity in lung cancer cells by specifically targeting TMPRSS4. Moreover, in vivo experiments confirmed that the combination of miR-149-3p and DDP exerts a stronger regulatory effect on TMPRSS4, reinforcing the conclusion that miR-149-3p enhances DDP sensitivity in lung cancer by inhibiting TMPRSS4.