Of interest, Abs against different NFs were found in 8 of 45 patients (17%), all with CNS disorders and, in most cases, against more than 1 NF (6/8, 75%), including heavy-chain NF (5/8, 62%), medium-chain NF (8/8, 100%), light-chain NF (6/8, 75%), α-internexin (4/8, 50%), and peripherin (1/2, 50%). The gene discussed is PRPH; the disease is central nervous system disorder.