CD8A and neoplasm: This finding is in line with one paper reporting that acetate enhances IFN-γ gene transcription and cytokine production, which rescued effector function in glucose-restricted tumor-infiltrating CD8+ T cells in an ACSS2-dependent manner.33 Similarly, Balmer et al. also showed that significantly increased serum acetate concentrations under the circumstances of bacterial systemic infection enhance glycolysis and cytosolic acetyl-CoA levels, which resulted in increased functional activity of CD8+ memory T cells.22