Although further study would be needed to confirm this hypothesis, it may be consistent with previous studies that have shown that CD8+ T-cells may infiltrate and contribute to viral clearance in the central nervous system during neurotropic ZIKV infection [44,45], as well as studies that have shown variability in the dependence of anti-ZIKV antibody development on T-cell help [20]. Here, CD8A is linked to Zika virus infectious disease.