These results call for further studies to understand the role of ceruloplasmin in the pathophysiology of ANCA-associated vasculitis, as well as larger retrospective or prospective studies to confirm our findings and to pursue the research of targeting of the ceruloplasmin/MPO complex in ANCA-associated vasculitis. The gene discussed is CP; the disease is anti-neutrophil cytoplasmic antibody-associated vasculitis.