PTK7 and scoliosis: Since the description of the first IS model in the zebrafish ptk7 gene mutant (Hayes et al., 2014), a number of mutants for genes encoding ciliary proteins were shown to develop scoliosis at late larval and juvenile stage (4–12 weeks post-fertilization, wpf) without any vertebral fusion or fracture, highlighting the link between cilia function and straight axis maintenance in that species (Grimes et al., 2016; Wang et al., 2022).