RF loss at embryonic stage in null sspo mutants generates ventral curvatures of the posterior axis of the body and is lethal while its loss at juvenile stage in hypomorphic sspo mutants triggers scoliosis with full penetrance (Cantaut-Belarif et al., 2018; Rose et al., 2020; Troutwine et al., 2020). Here, SSPOP is linked to scoliosis.