PSMB8 and neoplasm: Interestingly, the 3 main immunoproteasome genes, PSMB8, PSMB9, and PSMB10, which digest cellular protein to antigenic peptides for antigen presentation (2), were also upregulated by VC in the WT tumor cells, as indicated by PSMB8 (Figure 4G) and others (Supplemental Figure 4, E and F).