We performed molecular function pathway analysis for tumor clusters C0 and C2 and found major mechanisms associated with antigen presentation functions (such as MHC protein complex binding and MHC class II complex binding) enhanced by VC treatment (Supplemental Figure 2, E and F), which was lost in the TET2-KO tumor clusters (Supplemental Figure 2, G and H). This evidence concerns the gene TET2 and neoplasm.