TET2-KO clones for the CT-26 colon cancer cells were generated using CRISPR/Cas9 genome editing (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.175098DS1) and confirmed by both Western blotting and DNA sequencing (44). Here, TET2 is linked to malignant colon neoplasm.