RARA and acute promyelocytic leukemia: Promyelocytic leukemia protein (PML) was initially studied in the context of acute promyelocytic leukemia (APL), where specific chromosomal translocation t(15;17) occurs, resulting in the fusion of the PML gene with the retinoic acid receptor alpha (RARα; de Thé et al., 1990; Borrow et al., 1990).