This is possibly due to the difficulties in applying sometimes subjective radiologic criteria for tumor invasion, proliferative cutoffs that are prone to interobserver variability and are probably too low, the general trend away from p53 immunostaining due to a lack of any independent prognostic value in PitNETs, and the frequency with which radiologic information is unavailable to the pathologist at the time of diagnosis. Here, TP53 is linked to neoplasm.