However, in contrast to the well-known phenotype-genotype correlations observed in most gene fusion–driven neoplasms, there is still insufficient data on the morphological characteristics of FGFR3::TACC3 fusion–positive head and neck carcinomas and whether they display any degree of phenotype-genotype correlation that might be utilized to identify or suspect potential cases based on initial morphological evaluation in routine practice. The gene discussed is FGFR3; the disease is neoplasm.