Aldosterone production in human functional adrenocortical tumors (ACT) can be inferred immunohistochemically by staining for CYP11B2,2 with further characterization according to the type of lesion (nodules, micronodules, hyperplasia),3 and cortisol‐producing ACT in humans have altered expression of steroidogenic enzymes compared to normal adrenal glands and nonfunctional ACT.4, 5, 6, 7. This evidence concerns the gene CYP11B2 and adrenal cortex neoplasm.