SCF, the natural ligand of c-Kit with membrane-bound (mSCF) and soluble forms (sSCF) (Hsu et al., 1997), enhances the growth and migration of cancer cells such as cervical cancer (Aguilar et al., 2014), Ewing’s sarcoma (Landuzzi et al., 2000), and CRC (Yasuda et al., 2007). The gene discussed is KITLG; the disease is Ewing sarcoma.