A notable example of an alpha-beta switch was found in the gene Kctd13 (Fig. 3F; Fig. S4B), encoding a compo­­nent of a complex required for synaptic transmission (Escamilla et al., 2017) and implicated in neurodevelopmental disorders such as macrocephaly (Golzio et al., 2012) [although a subsequent study could not confirm the association with this latter phenotype (Escamilla et al., 2017)]. The gene discussed is KCTD13; the disease is neurodevelopmental disorder.