MAD2L1 plays a crucial role in chromosomal stability[59] and enhances the proliferative and migratory capabilities of tumor cells.[60, 61, 62, 63] Deficiency in MAD2L1 also leads to cellular senescence.[45, 60, 64] This study provides compelling evidence that loss of MAD2L1 hampered the growth of STS cells and induced senescence. Here, MAD2L1 is linked to neoplasm.