KIFC1 and neoplasm: Over the past decade, the identification of tumor markers has evolved, with cellular senescence now recognized as a hallmark of cancer.[48] Increasing evidence suggests that factors such as DNA damage, chromosomal instability, and other stressors can trigger cellular senescence.[49] While KIFC1's critical role in maintaining chromosomal stability has been well documented,[11] its involvement in cellular senescence has not been extensively studied.