In subgroup analysis, the sensitivity of [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT was higher compared to [<sup>99m</sup>Tc]Tc-MDP BS (0.98 vs. 0.86), while the specificity of [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT was also higher than [<sup>99m</sup>Tc]Tc-MDP BS (0.98 vs. 0.65).<h4>Conclusion</h4>Our meta-analysis demonstrates that PSMA PET/CT exhibits superior sensitivity and specificity in comparison with [<sup>99m</sup>Tc]Tc-MDP BS for identifying bone metastases in prostate cancer patients. This evidence concerns the gene FOLH1 and Familial prostate cancer.