SPRY4 and infection: The top upregulated genes in KSHV lytic and mixed infection spots are predicted to encode proteins that regulate angiogenesis including ADAMTS9, KDR and PGF, endothelial cell development including KDR and STC1, and cell-substrate adhesion, SPRY4, ITGA1, ADAMTS9, KDR, MMP12 (Fig. 6D and Fig. S3C).