In addition, a custom cell-type assignment termed ‘KS signature’ was generated from differentially expressed genes (DEGs) based on published bulk RNA sequencing datasets of KS samples (35, 36) that were further refined to identify the 5 top predictors of KSHV+ spots in the biopsy/PDX tissues: ADAMTS4, ADAM19, FLT4, STC1, CLEC4M (Fig. 6A, Table S2). Here, STC1 is linked to Kaposi's sarcoma.