As lysosomes play a key role in cells of the immune system, it is of special interest that several coding variants of BLTP3A are associated with susceptibility to systemic lupus erythematosus (SLE) (Gateva et al., 2009; Zhang et al., 2011; Wen et al., 2020), a chronic autoimmune disease. The gene discussed is BLTP3A; the disease is systemic lupus erythematosus.