HTT plays important roles in proteostasis (Harding and Tong, 2018), axonal transport (Vitet et al., 2020), transcription regulation (Benn et al., 2008), cellular stress responses (Liu and Zeitlin, 2017), and mitochondrial function (Carmo et al., 2018) and the expression of mHTT is considered responsible for the molecular pathogenesis cascade, including both loss of function and gain of toxic function, resulting in HD phenotypes in HD animal models and patients. This evidence concerns the gene HTT and Huntington disease.