Preliminary work has shown that ubiquitous expression of Abcd1 RNAi induced defects in pigment glia (glial cells that support photoreceptors) and led to progressive loss of photoreceptors.29 Additionally, other genes in the fly, namely bubblegum (bgm) and double-bubble (dbb), a pair of homologous acyl-CoA synthetases that catalyze VLCFA esterification to CoA preceding Abcd1 transport activity, have been studied to gain insight into ALD. This evidence concerns the gene ACSBG1 and adrenoleukodystrophy.