Previously, the focus has been on persons with hereditary pancreatitis, cystic fibrosis, or familial history of malignancies – i.e. PC, colorectal cancer- and specific mutations –BRCA1 and 2.AGA has pinpointed high-grade PCLs -namely PanIN III and high-grade IPMN- as the main targets for follow-up screening studies.27 The gene discussed is BRCA1; the disease is colorectal cancer.