IL37 and Cowden disease: Among the anti-inflammatory cytokines, IL-35 and IL-37 are highly effective in reducing inflammation in the intestinal tract.19 The research by Singh and co-workers shows that IL-2 is vital in immune responses, especially in autoimmune diseases like CD.20 However, Brown and others discovered that its level has decreased when different autoimmune diseases such as CD came into play, IL-37 implying it could be an inflammation suppressor or an immunoregulatory organizer for inflammation in a similar case.21