Moreover, there was an elevation in the activity of anti-oxidative enzymes, specifically SOD and GSH (<i>P</i><0.05), coupled with an enhanced expression of Nrf2 and HO-1 in the diabetic group (<i>P</i><0.01).<h4>Conclusion</h4>The study findings demonstrate that TFST can suppress oxidative stress by modulating the Nrf2 pathway and up-regulating HO-1 activity, thereby ameliorating diabetes-induced acute lung injury. This evidence concerns the gene HMOX1 and diabetes mellitus.