However, the specific roles and mechanisms of GSTM1 and GSTT1 in cisplatin induced AKI remain unclear.<h4>Methods</h4>To investigate the roles of GSTM1 and GSTT1 in cisplatin-induced AKI, we generated GSTM1 and GSTT1 knockout mice using CRISPR-Cas9 technology and assessed their kidney function under normal physiological conditions and cisplatin treatment. This evidence concerns the gene GSTM1 and acute kidney injury.