Blood samples were taken from allergic conjunctivitis patients and controls for total IgE, IL13 measurement and detection of <i>FOXP3</i> (rs3761548) gene polymorphism.<h4>Results</h4>There was a statistically significant difference between the allergic conjunctivitis group and healthy control group regarding <i>FOXP3</i> (rs3761548) polymorphism with those have AA genotype are 12 times at risk for allergic conjunctivitis and A allele increases the risk of allergic conjunctivitis by about 4 times. This evidence concerns the gene IGHE and atopic conjunctivitis.