The best cutoff values of total IgE and serum IL13 for detecting the severity of allergic conjunctivitis were ≥320 IU/ml and ≥40 Pg/ml and the area under the curve were 0.89 and 0.95 respectively.<h4>Conclusion</h4>The research significantly contributes to find correlation of <i>FOXP3</i> polymorphism, total IgE and IL13 with risk and severity of allergic conjunctivitis which are limited in the literature on the perceived value relevance of <i>FOXP3</i> polymorphism in allergic conjunctivitis risk and severity. This evidence concerns the gene IL13 and atopic conjunctivitis.