Under physiological conditions, we have previously reported that IFN-γ enhances hippocampal neurogenesis47 and induces neuronal differentiation.48 Notably, a recent study unveiled that CD8+ T cell-induced IFN-responsive oligodendrocytes and microglia play a crucial role in modifying white matter aging.49 Thus, the impact of CD8+ T cell-produced IFN-γ on neurogenesis and anxiety-like behaviour in HBV mice remains to be understood. Here, CD8A is linked to Anxiety.