The RASopathies, collectively, are a spectrum of genetic syndromes caused by mutations in genes involved in the RAS/ mitogen-activated protein kinase (MAPK) pathway, including but not limited to <i>PTPN11</i>, <i>NRAS</i>, <i>KRAS</i>, <i>HRAS</i>, <i>BRAF</i>, and <i>MAP2K1</i>. Here, MAP2K1 is linked to RASopathy.