MR analyses were performed using inverse-variance weighted, MR-Egger, and weighted median methods.<h4>Results</h4>The MR results revealed a significant causal effect of Macrophage Inflammatory Protein 1 Beta (MIP1β) on reducing the risk of postherpetic neuralgia (95%CI = 0.492-0.991, <i>p</i> = 0.044). The gene discussed is CCL4; the disease is postherpetic neuralgia.