The whole-brain analysis did not identify additional regions of food-cue-related response related to the examined genetic factors.<h4>Conclusion</h4>Children genetically at risk for obesity, as indicated by the <i>FTO</i> genotype, may be predisposed to higher food-cue-related reward responsivity in the lateral hypothalamus in the sated state, which, in turn, could contribute to overconsumption.<h4>Clinical trial registration</h4>https://clinicaltrials.gov/study/NCT03766191, identifier NCT03766191. This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.