Indeed, abnormal JAK-STAT activation has been linked to autoimmune diseases (such as systemic lupus erythematosus and rheumatoid arthritis), various cancers, and neuroinflammatory-associated diseases (such as multiple sclerosis and Parkinson's disease) (Hu et al. 2021; Sarapultsev et al. 2023). The gene discussed is SOAT1; the disease is multiple sclerosis.