Indeed, abnormal JAK-STAT activation has been linked to autoimmune diseases (such as systemic lupus erythematosus and rheumatoid arthritis), various cancers, and neuroinflammatory-associated diseases (such as multiple sclerosis and Parkinson's disease) (Hu et al. 2021; Sarapultsev et al. 2023). This evidence concerns the gene SOAT1 and rheumatoid arthritis.