The primary objective of the present study was to determine whether the relationship between attaining specific HbA1c targets (< 6.5%, 6.5–6.9%, and ≥ 8.0% compared to 7.0-7.9%) over time and risk of incident CAD is dependent on Hp phenotype in the Look AHEAD study, which represents a different demographic and clinical population and intervention. Here, HP is linked to coronary artery disorder.