In gastric cancer, 5-HT activation of the PI3K/Akt/mTOR signaling pathway induces increased expression of HIF1α and ABCD1, enhanced viability of gastric adenocarcinoma cells under metabolic stress, reduced cellular and lipid reactive oxygen clusters, and inhibited iron-dependent cell death [43]. The gene discussed is AKT1; the disease is gastric adenocarcinoma.