For example, in patients with pancreatic cancer, the glucocorticoid receptor (GR) was associated with high PD-L1 expression, low MHC-I expression, and poor survival, whereas depletion of tumor-specific GR or pharmacological inhibition of GR-sensitized pancreatic cancer in mice was associated with immunotherapy [53]. The gene discussed is CD274; the disease is familial pancreatic carcinoma.