Therefore, our result confirmed and extended the results previously reported on the association of CRP-albumin-based parameters, especially CAR, with mortality in older patients selected for specific diseases, such as acute and chronic heart failure [33], acute kidney injury (AKI) [34], chronic obstructive pulmonary disease (COPD) [35], Parkinson’s disease [36] and different types of cancers [37, 38]. The gene discussed is CRP; the disease is chronic obstructive pulmonary disease.