This reduction leads to reduced immune-killing cell infiltration and facilitates HNSCC progression and immune evasion.599 Yan et al. displayed that Irf6 loss triggered rapid HNSCC development in mouse models, while Notch/Ripk4/Irf6 axis activation suppressed tumor growth in vitro.600 These findings illustrate that IRF1, IRF2, IRF3, and IRF6 play an inhibitory effect on HNSCC. This evidence concerns the gene IRF2 and head and neck squamous cell carcinoma.