IRF1 plays a vital role in myeloid differentiation by acting as a tumor suppressor gene in leukemia, and mutations in IRF1 are likely to influence IRF1 and its DNA binding affinity, leading to the inhibition of cancer suppression.547 Semmes et al. identified IRF1 SNP as one risk locus in ALL.548. The gene discussed is ENSG00000280371; the disease is cancer.