Further studies demonstrated that IRF1 is a transcriptional regulator of ZBP1.271 Genes encoding IRF1, IRF5, and IRF7 are highly upregulated in patients with severe coronavirus disease-2019 (COVID-19), as well as in TNF-α and IFN-γ-treated bone-marrow-derived myeloid cells. This evidence concerns the gene ZBP1 and COVID-19.