IRF1 and acute respiratory distress syndrome: IRF1 knockout mice significantly abrogated pyroptosis in AMs and attenuated LPS-induced lung injury and systemic inflammation.817 Moreover, IRF1 deficiency strongly alleviated neutrophil extracellular traps (NETs) generation and ROS production in neutrophils from bronchoalveolar lavage fluid.818 Chen et al. showed that endothelial-specific Irf1 knockout in ALI mice presented lung endothelium regeneration.