PKD1 and autosomal dominant polycystic kidney disease: Of them, 14 (63.6%) presented causative variants, and it is interesting to note that 8 ADPKD patients with abnormal prenatal ultrasound findings carried variants in exon 15 and 46, two well-known mutational hot spots in the PKD1 gene, and 2 carried two in trans variants in the same gene.