While the interaction between NS1-BP and viral M1 mRNA decreases upon mutation of the pY-tract, NS1-BP can still interact with NS1 and hnRNP K. Low levels of NS1-BP or infection with influenza virus that lacks NS1 prevents proper M1 mRNA trafficking to nuclear speckles (13), which inhibits splicing of M1 to M2 mRNA (13, 14, 15, 18). The gene discussed is IVNS1ABP; the disease is infection.