Myelofibrosis MSCs were transcriptionally distinct, with significant enrichment of genes and pathways associated with myofibroblast transition including Acta2, KRAS and phosphoinositide-3-kinase (PI3K) signaling, inflammatory response genes and IL2-STAT5 signaling (Figs. 3C and 3D). This evidence concerns the gene ACTA2 and myelofibrosis.