NPPA and Hypertension: We next investigated the correlations between plasma mid-regional proANP (MR-proANP) concentrations and various plasma metabolites measured by metabolomics in the KORA cohort using linear regression models adjusted for age, sex, waist-to-hip ratio, physical activity, glomerular filtration rate, hypertension, and history of myocardial infarction on 1773 individuals (Fig. 8B and fig.